what does chromosome 2 determine

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The following is a partial list of genes on human chromosome 2. Older women are at higher risk of giving birth to babies with chromosome abnormalities than younger women. These changes can have a variety of effects on health and development, including intellectual disability, slow growth, characteristic facial features, weak muscle tone (hypotonia), and abnormalities of the fingers and toes. Chromosome 2 is one of the twenty-three pairs of chromosomes in humans. Omissions? Humans and most other mammals have two sex chromosomes, X and Y, that in combination determine the sex of an individual. For information on sex-linked characteristics, see linkage group. A fruit fly, for example, has four pairs of chromosomes, while a rice plant has 12 and a dog, 39. How do proteins,exactly,indicate the functions of cells and organisms?like how do they know if a certain gene is responsible for blonde hair or dark hair and how do they help these characterestics show themselves? Many chromosomes have two segments, called "arms," separated by a pinched region known as the centromere. Because the histones are positively charged, they attract negatively charged DNA which then wraps itself around the histones. 1;130A(4):331-9. doi: 10.1002/ajmg.a.30156. For a more satisfying answer, check out the articles and videos on the cell cycle and, Posted 7 years ago. LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, "What is Chromosome 2?". The signs and symptoms of this condition vary widely, but affected individuals generally have intellectual disability, behavioral problems, obesity, and skeletal abnormalities that often include unusually short fingers and toes (brachydactyly). Direct link to Kobehuang2024's post Meiosis is for sex cells , Posted 3 years ago. The evolutionary solution proposes that an end-to-end fusion of two small ape-like chromosomes (named 2A and 2B) produced human chromosome 2 (Figure 1). Thauvin-Robinet C, Arpin S, Le Caignec C, Jonveaux P, Beri M, Leporrier N, Motte The typical number of chromosomes in a human cell is 46: 23 pairs, holding an estimated total of 20,000 to 25,000 genes. Do all living things have the same types of chromosomes? RE. For instance, in humans, fetuses affected by polyploidy often are spontaneously aborted early in pregnancy. What i, Posted 2 years ago. Sex chromosomes determine an individual's sex: females have two X chromosomes (XX), and males have an X and a Y chromosome (XY). The techniques that were honed at a later date to obtain colored band and interband patterns in chromosomes revealed that our second largest chromosome is the result of a fusion of two chromosomes belonging to our closest evolutionary ancestors. Direct link to Neil Chaudhary's post In addition to what Aleks, Posted 7 years ago. MJ, Leheup B, Taine L, Lacombe D, Delrue MA, Toutain A, Paubel A, Mugneret F, Generation and annotation of the DNA sequences of human chromosomes 2 Direct link to 231434's post how does DNA get to the c, Posted 7 years ago. However, errors in cell division can result in cells with too few or too many copies of a chromosome. Chromosomes are truly huge swathes of DNA that have been compressed 1) in real life but also 2) on our chromosome depictions. 10.1016/j.ejmg.2005.07.001. autism spectrum disorder. Am J Hum Genet. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 2 spans 243 million base pairs and makes up around 8% of the total DNA present within our cells. Yes, they differ in a pair of chromosomes known as the sex chromosomes. In fact, each species of plants and animals has a set number of chromosomes. However, at the time, the nature and function of these cell structures were unclear. By continuing to browse this site you agree to our use of cookies. This article was most recently revised and updated by, https://www.britannica.com/science/chromosome, LiveScience - Chromosomes: Definition & Structure, Merck Manuals - Consumer Version - Genes and Chromosomes. DNA and chromosomes A cell's set of DNA is called its genome. Why do you think humans have two sets of 23 chromosomes? The chromosomes uncoil in the new cells, again forming the diffuse network of chromatin. Gaillard D, Doco-Fenzy M. The 2q37-deletion syndrome: an update of the clinical JF, Elsea SH. Changes in the number or structure of chromosomes in new cells may lead to serious problems. Available at: https://www.cancer.org/healthy/cancer-causes/genetics/family-cancer-syndromes.html (Accessed: 30 June 2022). 10.1002/ajmg.c.30153. No abstract The X and Y chromosomes, also known as the sex chromosomes, determine the biological sex of an individual: females inherit an X chromosome from the father for a XX genotype, while males inherit a Y chromosome from the father for a XY genotype (mothers only pass on X chromosomes). There are two main types of translocation. For example, a rearrangement (translocation) of genetic material between chromosomes 2 and 3 has been associated with cancers of a certain type of blood cell originating in the bone marrow (myeloid malignancies). This disease affects the blood and bone marrow. Direct link to Sean Cozart's post So cells go under mitosis, Posted 7 years ago. The haploid number is . What are chromosomes? They protect the ends of chromosomes in a manner similar to the way the tips of shoelaces keep them from unraveling. Our editors will review what youve submitted and determine whether to revise the article. This is where chromosomes are located. Humans normally have 46 chromosomes in each cell, divided into 23 pairs. The two chromosomes in a homologous pair are very similar to one another and have the same size and shape. These cells are only Haploid (n), meaning that they have half of the chromosomes that a regular somatic (body) cell has, which is know as Diploid (2n). Posted 4 years ago. The changes that occur are somatic, meaning they are acquired at some point throughout a persons lifetime rather than being present when a child is born (as inherited changes are). Epub 2016 Oct 24. Direct link to Darrielle Aaron's post Do you add haploid cells , Posted 2 years ago. Two copies of chromosome 2, one copy inherited from each parent, form one of the pairs. The nonliving viruses have chromosomes consisting of either DNA (deoxyribonucleic acid) or RNA (ribonucleic acid); this material is very tightly packed into the viral head. While the size of the deletion varies among affected individuals, it always contains a certain gene, called HDAC4. Following replication, the DNA condenses into chromosomes. The single chromosome of a prokaryotic cell is not enclosed within a nuclear membrane. Over 20'000 genes are recipes for proteins which are . Epub 2005 Aug 18. Physically speaking, DNA is a long string of paired chemical units (nucleotides) that come in four different types, abbreviated A, T, C, and G, and it carries information organized into units called. Several types of genetic changes are involved in SATB2-associated syndrome, all of which affect a gene on chromosome 2 called SATB2. What kind of chromosomes do all living things have? For example, in humans, one type of leukemia and some other cancers are caused by defective chromosomes made up of joined pieces of broken chromosomes. The DNA is copied. Updates? Corrections? The karyotype can help identify abnormalities in the structure or the number of chromosomes. This site complies with the HONcode standard for trustworthy health information: verify here. It appears to me that the amount of cells in a certain organ would just keep increasing and increasing. Once stained, the chromosomes look like strings with light and dark "bands," and their picture can be taken. For example, people with Down syndrome have three copies of chromosome 21, instead of the two copies found in other people. 10.1002/ajmg.a.30437. This cell then divides and its successors divide numerous times, eventually producing a mature individual with a full set of paired chromosomes in virtually all of its cells. Description. Chromosomes vary in number and shape among living things. When these bacteria invaded cells lacking the power to tap into oxygen's power, the cells retained them, and, over time, the bacteria evolved into modern-day mitochondria. Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, An increase or decrease in MBD5 protein disrupts gene expression that is normally well-controlled by this protein, which is likely why duplications and deletions of this gene lead to the same signs and symptoms. The remainder of this article pertains to eukaryotic chromosomes. Histone also play a part in gene activity. They are called sex chromosomes: Females have 2 X . "ring chromosome 2 syndrome". Hagemeijer A. Translocation t(2;3)(p15-23;q26-27) in myeloid malignancies: report Each is now considered its own chromosome. For example, humans are diploid (2n) and have 46 chromosomes in their normal body cells. In many types of cells, telomeres lose a bit of their DNA every time a cell divides. Learn.Genetics - Genetic Science Learning Center - How do Scientists Read Chromosomes? 1. Direct link to The Dogstar's post Sperm cells contain eithe, Posted 7 years ago. National Human Genome Research Institute: Chromosome Abnormalities. 2= diploid has, Posted 3 years ago. The human genome includes 21,000 or so genes, spread out along 3 billion base pairs of DNA. MC, Hennekam RC, Eng C, Dennis NR, Trembath RC. We inherit one set from each parent. Direct link to Neil Chaudhary's post There is a production of , Posted 7 years ago. As a real example, let's consider a gene on chromosome 9 that determines blood type (A, B, AB, or O) ^2 2. Get a Britannica Premium subscription and gain access to exclusive content. No In both processes, the correct number of chromosomes is supposed to end up in the resulting cells. Chromosome 1 is the designation for the largest human chromosome.Humans have two copies of chromosome 1, as they do with all of the autosomes, which are the non-sex chromosomes.Chromosome 1 spans about 249 million nucleotide base pairs, which are the basic units of information for DNA. Individuals affected by the condition ring chromosome 2 have delayed growth and development, a small head size (microcephaly), characteristic facial features, and heart defects. In the center of most cells is a structure called the nucleus. Deletions: A portion of the chromosome is missing or deleted. The final pair is called the "sex chromosomes." Am J Med Genet. Corrections? how does DNA get to the cells in the body? A numerical abnormality mean an individual is either missing one of the chromosomes from a pair or has more than two chromosomes instead of a pair. Several important diseases and conditions have been linked to gene abnormalities on chromosome 2, including maturity-onset diabetes of the young, primary pulmonary hypertension, and autism. Czepulkowski B, Saunders K, Pocock C, Sadullah S. Mosaic trisomy 2 in Most people with MAND also have behavior problems similar to autism spectrum disorder, a developmental condition that affects communication and social interaction. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. It is still made up of two sister chromatids, but they are now short and compact rather than long and stringy. phenotype-breakpoint correlations in 66 individuals. So, mitochondrial DNA is always inherited from the female parent. Like a recipe book, each chromosome contains a certain number of recipes, known as ' genes '. The deleted or duplicated segment varies in size but always contains the MBD5 gene, and often additional genes. growth retardation, mild dysmorphism, and microdeletion of 2p detected using The signs and symptoms of SATB2-associated syndrome are usually similar, regardless of the type of mutation that causes it. Chromosomes are the structures that hold genes. One molecule of DNA and one protein make up one chromosome. News-Medical. Inheriting too many or not enough copies of sex chromosomes can lead to serious problems. Partial list of the genes located on p-arm (short arm) of human chromosome 2: Partial list of the genes located on q-arm (long arm) of human chromosome 2: The following diseases and traits are related to genes located on chromosome 2: G-banding ideograms of human chromosome 2. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.[14]. You will need to look at the letters from chromosomes 12, 13, 14, and 15 to determine the eye color. One set of 23 chromosomes is inherited from the biological mother (from the egg), and the other set is inherited from the biological father (from the sperm). Robertson, Sally. While every effort has been made to follow citation style rules, there may be some discrepancies. 13;87(2):219-28. doi: 10.1016/j.ajhg.2010.07.011. What happens to a chromosome as a cell prepares to divide. Only egg cells - and not sperm cells - keep their mitochondria during fertilization. Within the primate family Hominidae, 24 pairs of chromosomes are seen in all species apart from humans and the extinct Neanderthals and Denisovan species, where 23 pairs of chromosomes make up the genome. Chromosomes are thread-like structures located inside the nucleus of animal and plant cells. Homologous chromosomes, sister chromatids, and haploid/diploid. Mol Genet Genomic Med. Image of a eukaryotic cell, showing the nuclear DNA (in the nucleus), the mitochondrial DNA (in the mitochondrial matrix), and the chloroplast DNA (in the stroma of the chloroplast). Some mutations remove genetic material from the long arm of chromosome 2. Males have 1 X and 1 Y chromosome. In most animals, however, any change from the typical chromosome number for a species may be accompanied by changessometimes drasticin the organism. "Search results - 14[CHR] AND "Homo sapiens"[Organism] AND ("has ccds"[Properties] AND alive[prop]) - Gene", Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3), "Between a chicken and a grape: estimating the number of human genes", "Statistics & Downloads for chromosome 14", "Chromosome 14: Chromosome summary - Homo sapiens", "Human chromosome 14: entries, gene names and cross-references to MIM", "Search results - 14[CHR] AND "Homo sapiens"[Organism] AND ("genetype protein coding"[Properties] AND alive[prop]) - Gene", "Search results - 14[CHR] AND "Homo sapiens"[Organism] AND ( ("genetype miscrna"[Properties] OR "genetype ncrna"[Properties] OR "genetype rrna"[Properties] OR "genetype trna"[Properties] OR "genetype scrna"[Properties] OR "genetype snrna"[Properties] OR "genetype snorna"[Properties]) NOT "genetype protein coding"[Properties] AND alive[prop]) - Gene", "Search results - 14[CHR] AND "Homo sapiens"[Organism] AND ("genetype pseudo"[Properties] AND alive[prop]) - Gene", "Concerted regulation of myofiber-specific gene expression and muscle performance by the transcriptional repressor Sox6", Ideogram data for Homo sapience (400 bphs, Assembly GRCh38.p3), Ideogram data for Homo sapience (550 bphs, Assembly GRCh38.p3), "Estimation of band level resolutions of human chromosome images", "The DNA sequence and analysis of human chromosome 14", 10.1002/(SICI)1096-8628(19991203)87:4<294::AID-AJMG2>3.0.CO;2-S, https://en.wikipedia.org/w/index.php?title=Chromosome_14&oldid=1133388512, This page was last edited on 13 January 2023, at 14:57. Chromosome 11 spans about 135 million DNA building blocks (base pairs) and represents between 4 and 4.5 percent of the total DNA in cells. These genetic changes disrupt the SATB2 gene and are thought to reduce the amount of functional protein produced from it. SH. Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea of 21 new cases, clinical, cytogenetic and molecular genetic features. Another syndrome caused by imbalance in the number of sex chromosomes is Turner syndrome. Genes are the individual instructions that tell our bodies how to develop and function; they govern physical and medical characteristics, such as hair color, blood type and susceptibility to disease. Can changes in the structure of chromosomes affect health and development? The chromosome condenses. For example, females who have extra copies of the X chromosome are usually taller than average and some have mental disability. In this interview, AZoM speaks to Rohan Thakur, the President of Life Science Mass Spectrometry at Bruker, about what the opportunities of the market are and how Bruker is planning on rising to the challenge. Of the 23 pairs of chromosomes, the first 22 pairs are called "autosomes." If you're behind a web filter, please make sure that the domains *.kastatic.org and *.kasandbox.org are unblocked. chromosome 2 and microdeletion of 2q detected using FISH: Further support for An organism's phenotype (physical traits and behaviors) are established by their inherited genes. [7][8][9] The evidence for this includes: We conclude that the locus cloned in cosmids c8.1 and c29B is the relic of an ancient telomere-telomere fusion and marks the point at which two ancestral ape chromosomes fused to give rise to human chromosome 2. Well the main type of cell that does not contain 46 chromosomes is the gamete cell that we use to reproduce, so our sperm or egg cells. Firstly, the banding (staining pattern) of chromosome 2 in humans is closely matched to that of two different chromosomes in the chimpanzee, gorilla, and orangutan. Errors can also occur when the chromosomes are being duplicated. Heres a link I found: In the first paragraph (DNA and Genomes), it says that. However, as soon as they are pulled apart during cell division, each is considered a separate chromosome. Most importantly, they carry the same type of genetic information: that is, they have the same genes in the same locations. Passed from parents to offspring, DNA contains the specific instructions that make each type of living creature unique. Can changes in the number of chromosomes affect health and development? Band length in this diagram is proportional to base-pair length. Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a MBD5 locus. Gastier-Foster J, Thrush DL, Kathiresan S, Ruderfer DM, Chiang C, Hanscom C, Please refer to the appropriate style manual or other sources if you have any questions. Chromosome 2 is the second-largest human chromosome, spanning more than 242 million base pairs[4] and representing almost eight percent of the total DNA in human cells. eCollection 2017 Sep. Talkowski ME, Mullegama SV, Rosenfeld JA, van Bon BW, Shen Y, Repnikova EA, In a Robertsonian translocation, an entire chromosome has attached to another at the centromere. (1991) "Origin of human chromosome 2: an ancestral telomere-telomere fusion.". Information about specific chromosomes chromosome 1 chromosome 2 chromosome 3 chromosome 4 chromosome 5 chromosome 6 chromosome 7 chromosome 8 chromosome 9 chromosome 10 chromosome 11 chromosome 12 chromosome 13 chromosome 14 These cells are said to be in "G-zero." Without such packaging, DNA molecules would be too long to fit inside cells. Search J Med Genet. The following chromosomal conditions are associated with changes in the structure or number of copies of chromosome 2. In sexually reproducing organisms, the number of chromosomes in the body (somatic) cells typically is diploid (2n; a pair of each chromosome), twice the haploid (1n) number found in the sex cells, or gametes. Reciprocal deletion and duplication at 2q23.1 indicates a role for MBD5 in Humans have 23 pairs of chromosomes, for a total of 46 chromosomes. This organizes and condenses the DNA, I believe this is for when the chromosomes duplicate. Vocabulary: autosome, chromosomal disorder, chromosome, karyotype, sex chromosome. Further examples of chromosomal 2 abnormalities include partial trisomy 2, where an additional piece of chromosome 2 is found in each cell, and partial monosomy 2, where a portion of the chromosome is missing. Among many organisms that have separate sexes, there are two basic types of chromosomes: sex chromosomes and autosomes. Humans, along with other animals and plants, have linear chromosomes that are arranged in pairs within the nucleus of the cell. 2q37 deletion syndrome occurs when genetic material is deleted from a specific region of chromosome 2, near the end of the long arm at location 2q37. Two copies of chromosome 11, one copy inherited from each parent, form one of the pairs. abstract available. For instance, the 46 chromosomes found in human cells have a combined length of 200 nm (1 nm = 10 9 metre); if the chromosomes were to be unraveled, the genetic material they contain would measure roughly 2 metres (about 6.5 feet) in length. The chromosomes of a eukaryotic cell consist primarily of DNA attached to a protein core. Breakage and reunion of homologous chromosomes during meiosis are the basis for the classical model of crossing over, which results in unexpected types of offspring of a mating. single causal locus of intellectual disability, epilepsy, and autism spectrum It is likely that any changes in MBD5 protein levels impair its regulation of gene expression, leading to the uncontrolled production of certain proteins. Direct link to eman.grine's post , Posted 5 months ago. The severity of symptoms typically depends on how many and which types of cells contain the ring chromosome 2. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). doi: 10.1136/jmg.38.9.e32. also, are the histones? Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. Most people know that the X chromosome is one of the two sex chromosomes; inherit an X from each of your parents and you will likely be deemed "biologically female." Get an X from your mother and a Y from your father and you will likely be deemed "biologically male." Direct link to Manoj kumar's post is DNA contain our physic, Posted 3 years ago. News-Medical, viewed 04 March 2023, https://www.news-medical.net/health/What-is-Chromosome-2.aspx. All cells start from the original fertilized zygote. Most human cells have 23 pairs of chromosomes. In this interview, we speak to Ceri Wiggins, a Director at AstraZeneca, about the many applications of CRISPR and its role in discovering new COPD therapies. Thus chromosomes as a whole play an important role in inheritance. Count up the total number of Capital E's and lower case e's and compare them to the genotype conversion chart. Mullegama SV, Rosenfeld JA, Orellana C, van Bon BW, Halbach S, Repnikova EA, Molecular cytogenetic analysis of five 2q37 deletions: refining the Compilation of the top interviews, articles, and news in the last year. These newer methods compare the patient's DNA to a normal DNA sample. patients. Direct link to Bushi's post chroma means colored and , Posted 6 years ago. Trisomy 2 has also been associated with hepatoblastoma, pleuropulmonary blastoma, and nasopharyngeal carcinoma. Nature. Individuals with this chromosome abnormality often have developmental delay, small head size (microcephaly), slow growth before and after birth, heart defects, and distinctive facial features. Williams SR, Aldred MA, Der Kaloustian VM, Halal F, Gowans G, McLeod DR, Other mutations, such as those that change single DNA building blocks (nucleotides) in the SATB2 gene, can also cause SATB2-associated syndrome. Meiosis is for sex cells or gametes (these cells don't have the same genetic makeup as the original germ cell), and mitosis is to copy and reproduce new cells resulting in the same genetic makeup as the original somatic cell. Identifying genes on each chromosome is an active area of genetic research. This can happen with or without loss of genetic material. Can you explain me the basic understanding about mitosis and meiosis? Please use one of the following formats to cite this article in your essay, paper or report: Robertson, Sally. As a result, the genetic material is inverted. This is the way most of the cells that make up our body are made and replaced. Duplications: A portion of the chromosome is duplicated, resulting in extra genetic material. The unique structure of chromosomes keeps DNA tightly wrapped around spool-like proteins, called histones. Direct link to Macie's post The general concept of mi, Posted 7 years ago. It is usually followed by reunion (frequently at a foreign site, resulting in a chromosome unlike the original). In Turner syndrome, a female is born with only one sex chromosome, an X, and is usually shorter than average and unable to have children, among other difficulties. DNA, chromosomes, and genomes. M, Romana SP. In this system, the sex of an individual is determined by a pair of sex chromosomes. 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Changes in chromosome 2 have been identified in several types of cancer. and genotype-phenotype correlation. Scientists looking at cells under the microscope first observed chromosomes in the late 1800s. To help identify chromosomes, the pairs have been numbered from 1 to 22, with the 23rd pair labeled "X" and "Y." J, Fiquet C, Brichet O, Mozelle-Nivoix M, Sabouraud P, Golovkine N, Bednarek N, It is also crucial that reproductive cells, such as eggs and sperm, contain the right number of chromosomes and that those chromosomes have the correct structure. Learn how and when to remove this template message, Hereditary nonpolyposis colorectal cancer, Infantile-onset ascending hereditary spastic paralysis, Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency, Mitochondrial trifunctional protein deficiency, "Search results - 2[CHR] AND "Homo sapiens"[Organism] AND ("has ccds"[Properties] AND alive[prop]) - Gene", Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3), "Generation and annotation of the DNAD sequences of human chromosomes 2 and 4", Vega Homo sapiens genome browser: HoxD cluster on Chromosome 2, "A high-coverage genome sequence from an archaic Denisovan individual", It has been hypothesized that Human Chromosome 2 is a fusion of two ancestral chromosomes, "Chromosome 2 in the Great Apes - YouTube", "Origin of human chromosome 2: an ancestral telomere-telomere fusion", "Between a chicken and a grape: estimating the number of human genes", "Statistics & Downloads for chromosome 2", "Chromosome 2: Chromosome summary - Homo sapiens", "Human chromosome 2: entries, gene names and cross-references to MIM", "Search results - 2[CHR] AND "Homo sapiens"[Organism] AND ("genetype protein coding"[Properties] AND alive[prop]) - Gene", "Search results - 2[CHR] AND "Homo sapiens"[Organism] AND ( ("genetype miscrna"[Properties] OR "genetype ncrna"[Properties] OR "genetype rrna"[Properties] OR "genetype trna"[Properties] OR "genetype scrna"[Properties] OR "genetype snrna"[Properties] OR "genetype snorna"[Properties]) NOT "genetype protein coding"[Properties] AND alive[prop]) - Gene", "Search results - 2[CHR] AND "Homo sapiens"[Organism] AND ("genetype pseudo"[Properties] AND alive[prop]) - Gene", "Largest Ever Autism Study Identifies Two Genetic Culprits", "Cleft Chin | AncestryDNA Traits Learning Hub", "Lowry-Wood syndrome: Further evidence of association with RNU4ATAC, and correlation between genotype and phenotype", "Photic Sneeze Reflex | AncestryDNA Traits Learning Hub", Ideogram data for Homo sapience (400 bphs, Assembly GRCh38.p3), Ideogram data for Homo sapience (550 bphs, Assembly GRCh38.p3), https://en.wikipedia.org/w/index.php?title=Chromosome_2&oldid=1138449158, The correspondence of chromosome 2 to two, This page was last edited on 9 February 2023, at 19:25.

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what does chromosome 2 determine